Hepatoprotective activity of curcuma xanthorrhiza Roxb. On paracetamol-induced liver damage in rats and correlation with their chemical compounds

Abstract

Background: Paracetamol (PCT) is a widely used drug, but at high dose, it can produce undesirable side effects such as hepatotoxicity. Curcuma xanthorrhiza Roxb. is the one of Indonesian medicinal plants that traditionally used to treat liver disorders. Aim of the Study: The present study was carried out to investigate the hepatoprotective activity of fresh rhizome decoction (FRD), dried rhizome decoction (DRD), essential oils, and curcumin of C. xanthorrhiza in Wistar albino rats. Materials and Methods: The liver toxicity was induced in rats using PCT. The blood samples and livers were collected and subjected to biochemical such as serum glutamic pyruvate transaminase (SGPT) and serum glutamic oxaloacetic transaminase (SGOT), gross macroscopical, and histopathological analysis. The chemical compounds and their hepatoprotective activity were correlated. Results: Among all samples, FRD showed better activity compared to the other samples with percentage protection of SGPT (99.45%) and SGOT (98.86%) level in a dose of 6.75 g/kg BW. Conclusions: From the results, it could be concluded that all the chemical compounds of C. xanthorrhiza have a hepatoprotective activity.