The effect of Leaf Salam Extracts (Syzygium polyanthum) in diabetes mellitus therapy on wistar albino rats

Abstract

Diabetes mellitus (DM) is one of the chronic disease that caused the most complications and even death. Non-Insulin Dependent Diabetes Mellitus (NIDDM) is the most widely recognized. It is closely related with the incidence of insulin resistance. This research is an in vivo experimental study with post-test control group design located in laboratory of animal house and biomolecular laboratory Faculty of Medicine, Universitas Sriwijaya, Indonesia. The subjects of this study were albino rats (Rattus norvegicus), Wistar strain, divided into 5 groups are negative control, positive control (TZD), Leaf Salam Extract (LSE) 50 mg/kgBW, 100 mg/kgBW and 200 mg/kgBW. Rat was injected by Human Insulin (ip) 1,8 IU/kgBW and orally glucose for 14 days. In this study it was found that there was no distinction in blood sugar levels in the positive control group with LSE 200 mg/kgBW, LSE 100 mg/kgBW and LSE 50 mg/kgBW and there were no difference in insulin levels in the positive control group with LSE 200 mg/kgBW and LSE 100 mg/kgBW and LSE 50 mg/kgBW. So, it can be concluded that LSE (Syzygium polyanthum) was effective in lowering blood sugar and insulin levels of Wistar albino rat induced diabetes mellitus.