Cytogenetic pattern of Acute Lymphoblastic Leukemia (All) in the Yogyakarta and Central Java Province, Indonesia

Abstract

The aim of this investigation is to analyse the cytogenetics of ALL patients. Cytogenetic analysis is important in determining the management of those patients. Fourteen ALL patients, hospitalised in several hospitals in Yogyakarta and Semarang since June 1992 to November 1992, were studied by G- banding method. The results showed 4 patients with structural abnormality t(9;22) (q34. 1;q11.21) (2 patients), t(4;11) (q21;q23) (1 patient), and del 11, p13-p14 (1 patient); 9 patient with numerical abnormality such as hyperploidy, polyploidy, tetraploidy and monosomy, three of them showed double abnormalities (structural and numerical); 4 patients with normal karyotype. Patients wich previously have hyperploidy > 50 Chromosom and normal karyotype, after treatment showed remission/partial remission. Patents with double abnormalities were clinically more progressive. It is concluded that structural chromosomal abnormality in ALL is important to determine the group and prognosis of the disease.