Lacrimal canalicular stenosis associated with systemic 5-fluorouracil therapy

Abstract

Purpose: Ocular side effects of systemic 5-fluorouracil therapy include excessive lacrimation which often resolves on cessation of therapy. Permanent stenosis of lacrimal puncta and canaliculi is rare. This report highlights this uncommon complication of 5-fluorouracil therapy. Methods: Report of two cases and review of literature. Results: Severe stenosis of puncta and canaliculi may be associated with prolonged systemic 5-fluorouracil therapy. Conclusion: It is important for both the oncologist and ophthalmologist to be aware of the potential ocular toxicity of 5-fluorouracil. Surgical management to relieve the epiphora is often challenging, and early intervention may be beneficial.