Validation of a clinical risk-scoring algorithm for severe scrub typhus

4Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

Objective: The aim of the study reported here was to validate the risk-scoring algorithm for prognostication of scrub typhus severity. Methods: The risk-scoring algorithm for prognostication of scrub typhus severity developed earlier from two general hospitals in Thailand was validated using an independent dataset of scrub typhus patients in one of the hospitals from a few years later. The predictive performances of the two datasets were compared by analysis of the area under the receiver-operating characteristic curve (AuROC). Classification of patients into non-severe, severe, and fatal cases was also compared. Results: The proportions of non-severe, severe, and fatal patients by operational definition were similar between the development and validation datasets. Patient, clinical, and laboratory profiles were also similar. Scores were similar in both datasets, both in terms of discriminating non-severe from severe and fatal patients (AuROC =88.74% versus 91.48%, P=0.324), and in discriminating fatal from severe and non-severe patients (AuROC =88.66% versus 91.22%, P=0.407). Over- and under-estimations were similar and were clinically acceptable. Conclusion: The previously developed risk-scoring algorithm for prognostication of scrub typhus severity performed similarly with the validation data and the first dataset. The scoring algorithm may help in the prognostication of patients according to their severity in routine clinical practice. Clinicians may use this scoring system to help make decisions about more intensive investigations and appropriate treatments. © 2014 Sriwongpan et al. This work is published by Dove Medical Press Limited.

Cite

CITATION STYLE

APA

Sriwongpan, P., Patumanond, J., Krittigamas, P., Tantipong, H., Tawichasri, C., & Namwongprom, S. (2014). Validation of a clinical risk-scoring algorithm for severe scrub typhus. Risk Management and Healthcare Policy, 7, 29–34. https://doi.org/10.2147/RMHP.S56974

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free