It is well established that plant phenolics elicit various biological activities, with positive effects on health. Palm oil production results in large volumes of aqueous by-products containing phenolics. In the present study, we describe the effects of oil palm phenolics (OPP) on several degenerative conditions using various animal models. OPP reduced blood pressure in a NO-deficient rat model, protected against ischaemia-induced cardiac arrhythmia in rats and reduced plaque formation in rabbits fed an atherogenic diet. In Nile rats, a spontaneous model of the metabolic syndrome and type 2 diabetes, OPP protected against multiple aspects of the syndrome and diabetes progression. In tumour-inoculated mice, OPP protected against cancer progression. Microarray studies on the tumours showed differential transcriptome profiles that suggest anti-tumour molecular mechanisms involved in OPP action. Thus, initial studies suggest that OPP may have potential against several chronic disease outcomes in mammals. © 2011 The Authors.
CITATION STYLE
Sambanthamurthi, R., Tan, Y., Sundram, K., Hayes, K. C., Abeywardena, M., Leow, S. S., … Basri Wahid, M. (2011). Positive outcomes of oil palm phenolics on degenerative diseases in animal models. British Journal of Nutrition, 106(11), 1664–1675. https://doi.org/10.1017/S0007114511002133
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