Positive outcomes of oil palm phenolics on degenerative diseases in animal models

30Citations
Citations of this article
79Readers
Mendeley users who have this article in their library.

Abstract

It is well established that plant phenolics elicit various biological activities, with positive effects on health. Palm oil production results in large volumes of aqueous by-products containing phenolics. In the present study, we describe the effects of oil palm phenolics (OPP) on several degenerative conditions using various animal models. OPP reduced blood pressure in a NO-deficient rat model, protected against ischaemia-induced cardiac arrhythmia in rats and reduced plaque formation in rabbits fed an atherogenic diet. In Nile rats, a spontaneous model of the metabolic syndrome and type 2 diabetes, OPP protected against multiple aspects of the syndrome and diabetes progression. In tumour-inoculated mice, OPP protected against cancer progression. Microarray studies on the tumours showed differential transcriptome profiles that suggest anti-tumour molecular mechanisms involved in OPP action. Thus, initial studies suggest that OPP may have potential against several chronic disease outcomes in mammals. © 2011 The Authors.

Cite

CITATION STYLE

APA

Sambanthamurthi, R., Tan, Y., Sundram, K., Hayes, K. C., Abeywardena, M., Leow, S. S., … Basri Wahid, M. (2011). Positive outcomes of oil palm phenolics on degenerative diseases in animal models. British Journal of Nutrition, 106(11), 1664–1675. https://doi.org/10.1017/S0007114511002133

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free