Journal ArticleOPEN ACCESS

Extraction and purification of 1-hydroxymidazolam glucuronide from ultrafiltrate

  • Mckenzie C
  • Naughton D
  • Davies G
  • et al.
Critical Care (2010) 14(Suppl 1) P512
DOI: 10.1186/cc8744
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Abstract

We developed a technique for detection of MDZ and 1-hydroxymidazolam glucuronide (1-OHMG). No commercial source of 1-OHMG prevented assay development. 1-OHMG had pharmacological activity and is renally excreted. We postulated that ultrafiltrate (UFR) would be rich in 1-OHMG. We describe a method to purify 1-OHMG from UFR.

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Mckenzie, C., Naughton, D., Davies, G., & Treacher, D. (2010). Extraction and purification of 1-hydroxymidazolam glucuronide from ultrafiltrate. Critical Care, 14(Suppl 1), P512. https://doi.org/10.1186/cc8744

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