Abstract
Chymase released from mast cells produces pro-fibrotic, inflammatory, and vasoconstrictor agents. Studies were performed to test the hypothesis that chronic chymase inhibition provides a renal protective effect in type 2 diabetes. Diabetic (db/db) and control mice (db/m) were chronically infused with a chymase-specific inhibitor or vehicle for 8 weeks. Baseline urinary albumin excretion (UalbV) averaged 42 ± 3 and 442 ± 32 microg/d in control (n = 22) and diabetic mice (n = 27), respectively (p
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Bivona, B. J., Takai, S., Seth, D. M., Satou, R., & Harrison-Bernard, L. M. (2019). Chymase inhibition retards albuminuria in type 2 diabetes. Physiological Reports, 7(24). https://doi.org/10.14814/phy2.14302
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