Acute motor-dominant polyneuropathy as Guillain-Barré syndrome and multiple mononeuropathies in a patient with Sjögren’s syndrome

Abstract

A patient with xerostomia and xerophthalmia due to Sjögren’s syndrome presented with acute motordominant polyneuropathy and multiple mononeuropathy with antiganglioside antibodies. Nerve conduction studies and a sural nerve biopsy revealed the neuropathy as a mixture of segmental demyelination and axonal degeneration. Positive results were obtained for several antiganglioside antibodies. Corticosteroid treatment proved effective. The neuropathy was considered to represent a mixture of polyneuropathy as Guillain-Barré syndrome and multiple mononeuropathy via Sjögren’s syndrome. We speculate that Guillain-Barré syndrome occurred in the patient and Guillain-Barré syndrome itself activated multiple mononeuropathy via Sjögren’s syndrome.