Physicochemical Manipulation for Effective Nucleic Acid Therapeutics --Toward Material Symbiosis with Nucleic Acid Drugs—

Abstract

In recent years, nucleic acid drugs have gained a great deal of attention as a new drug discovery platform. With sophisticated artificial nucleic acid technology, issues such as 1） target affinity and selectivity, 2） in vivo stability, and 3） side effects such as immune response have been overcome one by one, and the expansion of indications is being vigorously pursued. On the other hand, even highly optimized nucleic acid drugs are still associated with side effects and have yet to be widely used. In this paper, we will discuss some known physicochemical interactions between nucleic acid drugs and living organisms to find clues for the development of more effective and safer nucleic acid drugs, which we refer to as “For realizing Material Symbiosis with nucleic acid drugs.”