Severe hypoglycemia and diabetic ketoacidosis in adults with type 1 diabetes: Results from the T1D exchange clinic registry

Abstract

Context: Few studies have assessed factors associated with severe hypoglycemia (SH) and diabetic ketoacidosis (DKA) in adults with type 1 diabetes (T1D). Objective: Our objective was to determine frequency of and factors associated with the occurrence of SH and DKA in adults with T1D. Design and Setting: We conducted a cross-sectional analysis from the T1D Exchange clinic registry at 70 U.S. endocrinology centers. Patients: Analysis included 7012 participants in the T1D Exchange clinic registry aged 26 to 93 years old with T1D for ≥2 years. Results: Higher frequencies of SH and DKA were associated with lower socioeconomic status (P < .001). SH was strongly associated with diabetes duration (P <7.0% (<53 mmol/mol) or <7.5% (<58 mmol/mol). DKA frequency increased with higher HbA1c levels (P