Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity

Abstract

Background: Lysophosphatidic acid (LPA) is a bioactive lipid with pleiotropic activities due to activation of six receptors (LPA1-6). Results: Genetic deletion and pharmacological blockade of LPA1 inhibit differentiation and bone degradation activity of osteoclasts. Conclusion: LPA controls bone homeostasis through the activation of LPA1 expressed by osteoclasts. Significance: LPA1 is a new therapeutic target of diseases with excess bone degradation. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.