COMPARISON OF LIQUISOLID AND INCLUSION COMPLEXATION TECHNIQUE FOR DISSOLUTION RATE ENHANCEMENT OF VALSARTAN

Abstract

The objective of this study is to screening of suitable non volatile liquid vehicle for the formulation of liquisolid tablets such as propylene glycol, polyethylene glycol 400 and tween 80 by using mathematical equations for enhancement of dissolution rate of drug and comparison of liquisolid technique with inclusion complex of β-cyclodextrin. Different liquisolid compacts were prepared using a mathematical model for calculating required quantities of powder and liquid ingredients to produce an acceptably flow able and compressible admixture. The prepared liquisolid systems were evaluated for their pre compression and post compression parameters. The drug-excipient interactions studies carried out by Infrared spectroscopy (IR) and X- ray diffraction (XRD). The maximum solubility of valsartan was found to be in propylene glycol. The liquisolid formulations containing propylene glycol as a non volatile solvent showed higher drug release. The IR studies confirmed that there was no interaction between the drug and excipients. The XRD analysis confirmed formation of a solid solution inside the compact matrix. All the pre compression and post compression properties of the liquisolid compacts were within the acceptable limits. Liquisolid technique can be used to improve the dissolution rate and bioavailability of low soluble drugs.