Compartments and Connections Within the Germinal Center

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Abstract

Protective high affinity antibody responses emerge through an orchestrated developmental process that occurs in germinal centers (GCs). While GCs have been appreciated since 1930, a wealth of recent progress provides new insights into the molecular and cellular dynamics governing humoral immunity. In this review, we highlight advances that demonstrate that fundamental GC B cell function, selection, proliferation and SHM occur within distinct cell states. The resulting new model provides new opportunities to understand the evolution of immunity in infectious, autoimmune and neoplastic diseases.

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Kennedy, D. E. (2021, March 31). Compartments and Connections Within the Germinal Center. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2021.659151

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