A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas

Keith Smith; Gamal A. El-Hiti; Amany S. Hegazy; Benson Kariuki

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A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas

Beilstein Journal of Organic Chemistry (2011) 7 1219-1227

DOI: 10.3762/bjoc.7.142

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Abstract

Lithiation of N'-benzyl-N,N-dimethylurea and its substituted derivatives with t-BuLi (3.3 equiv) in anhydrous THF at 0 °C followed by reaction with various electrophiles afforded a range of 3-substituted isoindolin-1-ones in high yields. © 2011 Smith et al; licensee Beilstein-Institut.

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Smith, K., El-Hiti, G. A., Hegazy, A. S., & Kariuki, B. (2011). A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N’-benzyl-N,N-dimethylureas. Beilstein Journal of Organic Chemistry, 7, 1219–1227. https://doi.org/10.3762/bjoc.7.142

A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas

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