Combination of XRCC1, GSTM1 and GSTT1 genetic polymorphisms and susceptibility to male breast cancer

Abstract

Male breast cancer is an uncommon disease that has been the focus of limited research. In the present study, we specifically investigated whether combination of common genetic variants in the X-ray repair cross-complementation group 1 gene (XRCC1; exon 10, codon 399 Arg/Gln and exon 6, codon 194 Arg/Trp) and loss-of-function deletion polymorphisms in glutathione S-transferases T1 (GSTT1) and M1 (GSTM1), were associated with an altered risk of male breast cancer. Blood samples from 10 males with breast cancer and 15 age- and sex-matched healthy persons were collected. The GSTM1, GSTT1 and XRCC1 genotypes were determined using PCR-based method. The null genotypes of GSTM1 and GSTT1 and 399Gln and 194Trp alleles of XRCC1 assumed as high-risk genotypes and alleles. Statistical analysis showed that the χ 2 for linear trend for 0, 1, 2 and 3 putative high-risk genotypes is equal to 5.673 (p = 0.017). © Academic Journals Inc., USA.