Formulasi Spray Gel Ekstrak Etanol Batang Etlingera rubroloba Menggunakan HPMC sebagai Gelling Agent

Abstract

Herbal plants are one source of discovering secondary metabolites for active ingredients in medicine and one of them is Etlingera rubroloba from the Zingiberaceae group. The stems of these plants contain polyphenols as natural antioxidants. Application of natural antioxidants can be given topically through spray gel preparations. Spray preparations in gel form using HPMC can produce clear visuals, stable viscosity and do not irritate the skin. This study aims to obtain the optimal concentration of HPMC in the manufacture of E.rubroloba ethanol extract spray gel in terms of the resulting evaluation and physical stability. Formulation of spray gel based on the experimental method of optimizing gel base by adding E.rubroloba ethanol extract in various concentrations of HPMC 0.1% (F1); 0.2% (F2); 0.3% (F3) ; 0.4% (F4); and 0.5% (F5). The results showed that F1 with 0.1% HPMC had the best physical properties and stability of the preparation with a clear organoleptic, characteristic odor, and slightly viscous, producing a homogeneous spray gel, having a pH of 6, viscosity of 60 cps, spray weight of 0.13 gram, dry time 1.14 minutes, pattern and diameter of spraying spread well, and physically stable through centrifugation method stability test and cycling test.