Accelerated solvent extraction of vitamin K1 in medical foods in conjunction with matrix solid-phase dispersion

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Abstract

An extraction technique is described for vitamin K1 in medical foods, using accelerated solvent extraction (ASE) in conjunction with matrix solid-phase dispersion (MSPD). The medical food sample is treated as it would be with MSPD extraction, followed by ASE for a hands-free automated extraction. The vitamin K1 in the ASE extract is then quantitated by reversed-phase liquid chromatography with fluorescence detection. The chromatography specifications are identical to those in previous work that used MSPD only, with a limit of detection of 6.6 pg and a limit of quantitation of 22 pg on column. Recoveries, which were determined for an analyte-fortified zero control reference material for medical foods, averaged 97.6% (n = 25) for vitamin K1. The method provides a rapid, automatic, specific, and easily controlled assay for vitamin K1 in fortified medical foods with minimal solvent usage.

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Chase, G. W., & Thompson, B. (2000). Accelerated solvent extraction of vitamin K1 in medical foods in conjunction with matrix solid-phase dispersion. Journal of AOAC International, 83(2), 407–410. https://doi.org/10.1093/jaoac/83.2.407

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