Estimating the Shape of the Fetal Pulse Curve for Transabdominal Pulse Oximetry using Synchronous Averaging

Abstract

A sufficient oxygen supply of the fetus is necessary for a proper development of the organs. Transabdominal fetal pulse oximetry is a method that allows to measure the oxygenation of the fetal blood non-invasively by placing the light sources and photodetectors on the belly of the pregnant woman. The shape of the measured fetal pulse wave is needed to extract parameters for the estimation of the oxygen saturation. This work presents an extension of our previously presented signal processing strategy that allows to extract an average shape of the fetal pulse wave from noisy mixed photoplethysmograms (PPG) with dominating maternal and very weak fetal signal components. An adaptive noise canceller and a comb filter are used to suppress the maternal component. The quality of the resulting fetal signal is sufficient to identify single pulse waves in time domain. Further processing demonstrates the extraction of the mean shape of a single fetal pulse wave by synchronous averaging of several detected pulses. The method is evaluated with different datasets of several simulated and synthetic signals measured with a tissue mimicking phantom. The feasibility of the approach is demonstrated by preparing the mixed PPGs to perform fetal pulse oximetry in future studies. However, clinical measurements are needed to finally evaluate the proposed system beyond synthetic datasets.