Urosepsis

Abstract

Sepsis is still a clinical condition complicated by high mortality. Early diagnosis and casual treatment are crucial. Urosepsis is defined as sepsis caused by a urogenital tract infection. Urosepsis in adults comprises approximately 25 % of all sepsis cases, and in most cases is due to complicated urinary tract infections. Septic shock is a critical situation, with a reported mortality rate nowadays still ranging from 30 % to 40 %. Urosepsis is in major of cases as a result of infection of urinary tract and obstructed uropathy of the upper urinary tract, by ureterolithiasis as the most common cause. Treatment of urosepsis comprises four major aspects: (i) early diagnosis; (ii) early goal-directed therapy including optimal pharmacodynamic exposure to antimicrobials; (iii) identification and control of the complicating factor in the urinary tract; and (iv) fluid therapy.