Exame imuno-histoquímico na biópsia de medula óssea: Uma importante ferramenta complementar à morfologia

Abstract

Due to historical and technical reasons, the use of immunohistochemistry (IHC) in bone marrow biopsies (BMB) has not till recently been introduced in diagnostic evaluation. However, this scenario has changed owing to the exponential growth in the number of antibodies available for paraffin-embedded material and the development of techniques for antigen retrieval and material decalcification. Not only does this text aim to assist pathologists in the selection/interpretation of antibody panels used in routine laboratories, but it also lists literature references highly useful for diagnostic practice in accordance with the author's experience.