ESPGHAN 57th Annual Meeting Abstracts

Abstract

Coeliac Disease RISK FACTORS FOR AUTOIMMUNE DISEASES IN PEDIATRIC ONSET CELIAC DISEASE Ferass Abu Hanna1, Maia Sirkin2, Bar Sofer3, Rania Egbarieh1, Sameh Tatour1, Avishay Lahad1, Sarit Peleg4, Tal Almagor1, Firas Rinawi1 1Emek Medical Center, Afula, Israel, 2Children's Hospital at Montefiore, New York, United States of America, 3Faculty of Medicine Technion, Haifa, Israel, 4Haifa And West Galilie District, Clalit Health Services, Haifa, Israel Objectives and Study: Objectives: Patients with Celiac disease (CeD) have an increased risk of developing other autoimmune diseases (ADs), however risk factors and predictors for ADs remain unclear. SUPRANUCLEAR LYMPHOCYTE COUNTİNG AND İNFİLTRATİON PATTERN PROVİDES A MORE RELİABLE AND ACCURATE PREDİCTİON Gül Çirkin1, Fatih Yılmaz2, Kadri Atay3 1Tepecik Training and Research Hospital, izmir, Turkey, 2Pathology Laboratory, Mardin Training and Research Hospital, izmir, Turkey, 3Gastroenterelogy, Mardin Training and Research Hospital, Mardin, Turkey Objectives and Study: Aim: Current intraepithelial lymphocyte (IEL) thresholds used for diagnosing celiac disease (CD) have limited specificity. PROSPECTIVE DATA FROM THE PREVENTCD STUDY Stephan Kok1, Renata Auricchio2, Gemma Castillejo3, Ester Donat4, Reut Klein5, Sibylle Koletzko6, Ilma Korponay-Szabó7, Eva Martínez-Ojinaga8, M Luisa Mearin1, Isabel Polanco8, Hein Putter9, Carmen Ribes-Koninckx4, Virginia Rodriguez1, Raanan Shamir5, Hania Szajewska10, Riccardo Troncone2, Katharina Werkstetter6, Carolien Meijer1 1Pediatric Gastroenterology, Willem Alexander Children's Hospital, Leiden University Medical Center, Leiden, Netherlands, 2Translational Medical Sciences And European Laboratory For The Investigation Of Food-induced Disease, University Federico II Naples, Naples, Italy, 3Paediatric Gastroenterology Unit, Hospital Universitario Sant Joan de Reus, Reus, Spain, 4Pediatric Gastroenterology Unit, La Fe Hospital, Valencia, Spain, 5Institute For Gastroenterology, Nutrition And Liver Disease, Schneider Children's Medical Center, School of Medicine, Faculty of Medical Sciences and Health, Tel Aviv University, Tel Aviv, Israel, 6Pediatric Gastroenterology And Hepatology, Ludwig Maximilian's University Munich Medical Center, Dr. von Hauner Children's Hospital, Munich, Germany, 7Coeliac Disease Center, Heim Pál National Paediatric Institute, Budapest, Hungary, 8Paediatric Gastroenterology And Nutrition, La Paz University Hospital, Madrid, Spain, 9Medical Statistics, Leiden University Medical Center, Leiden, Netherlands, 10Pediatrics, The Medical University of Warsaw, Warsaw, Poland Objectives and Study: Prospective cohort studies suggest that coeliac disease (CD) develops early in life, mainly before puberty. In September 2023 and 2024, luteinizing hormone (LH) was determined in previously collected samples to assess puberty development (LH ≥ 0.3mU/L). Since the onset of puberty usually occurs between 8-13 (girls) and 9-14 years (boys), children <8 years were considered pre-puberal and those >15 years were considered adolescent.