In vitro activities at pH 5.0 and pH 7.0 and in vivo efficacy of flucytosine against Aspergillus fumigatus

Paul E. Verweij; Debbie T.A. Te Dorsthorst; Willem H.P. Janssen; Jacques F.G.M. Meis; Johan W. Mouton

Journal ArticleOPEN ACCESS

In vitro activities at pH 5.0 and pH 7.0 and in vivo efficacy of flucytosine against Aspergillus fumigatus

Antimicrobial Agents and Chemotherapy (2008) 52(12) 4483-4485

DOI: 10.1128/AAC.00491-08

25Citations

25Readers

Abstract

The antifungal agent flucytosine was found to be active in vitro against Aspergillus fumigatus isolates when the MIC was determined at pH 5.0 instead of pH 7.0. The in vitro MIC at pH 5.0 corresponded to the in vivo efficacy of flucytosine monotherapy in a murine model of invasive aspergillosis. Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Cite

CITATION STYLE

APA

Verweij, P. E., Te Dorsthorst, D. T. A., Janssen, W. H. P., Meis, J. F. G. M., & Mouton, J. W. (2008). In vitro activities at pH 5.0 and pH 7.0 and in vivo efficacy of flucytosine against Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy, 52(12), 4483–4485. https://doi.org/10.1128/AAC.00491-08

In vitro activities at pH 5.0 and pH 7.0 and in vivo efficacy of flucytosine against Aspergillus fumigatus

Abstract

Cite

Register to see more suggestions