The purpose of this study was to synthesize a water-soluble derivative of rutin (compound 2) by introducing carboxylate groups on rutin's sugar moiety. The rutin derivative showed an almost 100-fold solubility increase in water. The antiradical capacity of compound 2 was evaluated using the luminol/AAPH system, and the derivative's activity was 1.5 times greater than that of Trolox®. Despite the derivative's high solubility in water (log P = -1.13), lipid peroxidation of brain homogenate membranes was very efficiently inhibited (inhibition values were only 19% lower than the inhibition values of rutin).
CITATION STYLE
Pedriali, C. A., Fernandes, A. U., Bernusso, L. D. C., & Polakiewicz, B. (2008). The synthesis of a water-soluble derivative of rutin as an antiradical agent. Quimica Nova, 31(8), 2147–2151. https://doi.org/10.1590/S0100-40422008000800039
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