Association between hyperlipidemia and calcium oxalate lower urinary tract uroliths in dogs

Abstract

Background: Metabolic syndrome is associated with formation of calcium oxalate (CaOx) uroliths in humans. Objectives: To investigate the association between obesity and hyperlipidemia with CaOx lower urinary tract uroliths in client-owned dogs. Animals: Dogs with (n = 55, U [uroliths]-dogs) and without (n = 39, UF [uroliths-free]-dogs) CaOx lower urinary tract uroliths. Methods: Case-control study. U-dogs were retrospectively enrolled and compared to UF-dogs. Body condition score (BCS; 1-9 scoring scale), serum triglyceride (TG) and total cholesterol (CH) concentrations and glycemia (after >12-hour food withholding) were recorded in both groups. Results: On univariate logistic regression, when excluding Miniature Schnauzers, odds of having uroliths increased by a factor of 3.32 (95% CI 1.38-11.12) for each mmol/L of TG (P =.027), of 39 (95% CI 9.27-293.22) for each mmol/L of glycemia (P