Spy: Vs. spy: Selecting the best reporter for 19F NMR competition experiments

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Abstract

Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive 19F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.

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De Castro, G. V., & Ciulli, A. (2019). Spy: Vs. spy: Selecting the best reporter for 19F NMR competition experiments. Chemical Communications, 55(10), 1482–1485. https://doi.org/10.1039/c8cc09790a

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