Role of Combined Blood Neutrophil- Lymphocyte Ratio and C-reactive Protein in Diagnosis of Spontaneous Bacterial Peritonitis

Abstract

Ascites is the most common complication of cirrhosis, constitutes the first manifestation of disease in the majority of patients and is the most common cause of hospitalization in the cirrhotic patient. Bacterial infection of ascites in the cirrhotic patient’s increases mortality up to four fold, The aim of the study is to assess the clinical usefulness of C - reactive protein and Neutrophil- Lymphocyte Ratio in diagnosis of ascetic fluid infection, this is cross-sectional study that was conducted in the Department of Hepatology, Gastroenterology and Infectious diseases-Banha university hospital .The study was carried out on 140 Patients with chronic liver disease, divided in to two groups according to presence or absence of SBP, the results revealed that there was statistical significant difference between two studied groups regarding WBCs, neutrophils, hemoglobin and CRP, Basal CRP level is generally higher in patients with SBP than without SBP. During bacterial infections CRP level rises and we concluded that Combined NLR and CRP could be used as a novel, simple, low-cost, non-invasive test for SBP diagnosis.