Synthesis and synthetic applications of biologically interesting rhodanine and rhodanine-based scaffolds

Abstract

Rhodanine and thiazolidinone (TZD) heterocycles are attractive targets in organic and medicinal chemistry owing to their potency in a wide spectrum of biological activities and can also serve as synthetic intermediates for many kinds of pharmaceuticals or drug precursors. Consequently, looking for efficient and concise green methods for the synthesis of these types of compounds is a major challenge in chemistry. As a result, many green methods have been used to synthesize structurally complex and diverse rhodanine and TZDs in recent years. The purpose of this chapter is to discuss the recent green synthesis of the rhodanine and TZD heterocyclic scaffolds including aqueous medium synthesis, ionic liquid, microwave, ultrasonic irradiation, solvent-free methods, solid catalysts, such as mesoporous, magnetic nanoparticles, etc.