Synthesis and structure-activity relationships of 2-azetidinone-l-sulfonic acid derivatives with a heteroatom-bound substituent at the 4-position

Abstract

The synthesis and antibacterial activity of 3-[(Z)-2-alkoxyimino-2-(2-aminothiazol-4-yl)-acetamido]-2-azetidinone-l-sulfonic acid derivatives with a heteroatom-bound substituent at the 4-position are described. The effect of various 4-substituents on the antibacterial activity was examined. Some of these compounds showed excellent antibacterial activity especially against Gram-negative bacteria, including β-lactamase-producing strains. © 1985, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.