A carbon-13 CP/MAS nuclear magnetic resonance study of several 1,4-disubstituted benzenes in the solid state

Abstract

The carbon-13 chemical shifts of several 1,4-disubstituted benzenes in the solid state are reported. At least one of the substituents is unsymmetrical and in most cases this leads to different 13 C chemical shifts of C-2 and C-6 and in some cases to different shifts for C-3 and C-5. The 13 C chemical shifts observed in the solid state are compared with those measured in solution and, where possible, with those obtained in low temperature solution studies where internal rotation of the unsymmetrical substituent is slow on the 13 C chemical shift time scale. Agreement between the chemical shifts observed in the solid state and solution is excellent. The potential application of CP/MAS nuclear magnetic resonance in deducing the conformation of benzene derivatives with two unsymmetrical substituents is discussed. Keywords: carbon-13 CP/MAS NMR, 13 C NMR chemical shifts, substituent effects.