Rapid diagnosis of azole-resistant aspergillosis by direct PCR using tissue specimens

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Abstract

We report the use of PCR techniques on a formalin-fixed and paraffin-embedded tissue specimen for direct detection of one dominant azole resistance mechanism in a case of disseminated invasive aspergillosis. Rapid detection of mutations associated with azole resistance directly in tissue significantly reduces diagnostic delay. Copyright © 2010, American Society for Microbiology. All Rights Reserved.

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Van Der Linden, J. W. M., Snelders, E., Arends, J. P., Daenen, S. M., Melchers, W. J. G., & Verweij, P. E. (2010). Rapid diagnosis of azole-resistant aspergillosis by direct PCR using tissue specimens. Journal of Clinical Microbiology, 48(4), 1478–1480. https://doi.org/10.1128/JCM.02221-09

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