Dietary Lipids Induce Ferroptosis in Caenorhabditiselegans and Human Cancer Cells

Abstract

Ferroptosis is a form of regulated cell death associated with oxidized lipids. Perez et al. report that the ingestion of polyunsaturated fatty acids can trigger ferroptosis in C. elegans germ cells and human cancer cells. In both systems, endogenous ether lipids protect cells from ferroptotic cell death.