Analysis of survival among biopsy-determined categories of kidney disease in dogs

Abstract

Background: There are many causes of kidney disease in dogs. The association of the diagnostic category with survival is unknown. Objective: Determine survival outcomes for biopsy-determined diagnostic categories of kidney disease in dogs. Animals: Six hundred forty-nine dogs were biopsied for evaluation of kidney disease. Methods: Retrospective study. Survival information was obtained for dogs whose kidney biopsy was submitted to the International Veterinary Renal Pathology Service between 2008 and 2018. Signalment, serum creatinine (sCr), urine protein : creatinine ratio (UPCR), and serum albumin (sAlb) were reported at the time of biopsy. Cox proportional hazards analysis was performed for the 14 categories with >10 cases having follow-up to determine hazard ratios (HR), using focal segmental glomerulosclerosis (FSGS) as baseline. Results: The median survival time (MST) for all dogs with follow-up (n = 649) was 608 days (interquartile range [IQR]: 109-1475 days). The most follow-up was obtained for FSGS (n = 138, MST 536 days). Dogs with renal amyloidosis (n = 80) had the shortest survival (MST 76 days, IQR 8-299 days) and, in the multivariate analysis including age, sCr, sAlb, and UPCR, an increased risk of death (HR 1.79 [95% CI: 1.22-2.65], P