ATM: An unexpected tumor-promoting factor in HER2-expressing tumors

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Abstract

ATM kinase is a gatekeeper of genome stability. However, its role in several other signaling pathways suggests that it might not always act as a tumor suppressor. Here, we discuss recent data that unveil a function of ATM as a tumor promoter in HER2-positive breast cancer.

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Stagni, V., Oropallo, V., & Barilà, D. (2016). ATM: An unexpected tumor-promoting factor in HER2-expressing tumors. Molecular and Cellular Oncology, 3(2). https://doi.org/10.1080/23723556.2015.1054551

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