Single-Day Praziquantel Therapy for Neurocysticercosis

Abstract

To the Editor: Administration of praziquantel for 15 days is effective therapy for patients with parenchymal brain cysticercosis.1 Because the plasma and cerebrospinal fluid concentrations of praziquantel are highest two hours after its administration, after which they decline rapidly,2,3 we hypothesized that a high concentration that was maintained for about six hours by giving three doses at two-hour intervals might increase the length of time the parasite was exposed to high concentrations of drug and be sufficient cysticidal therapy for these patients. We therefore treated 10 patients (6 women and 4 men; mean [±SD] age, 33±11 years) with parenchymal . . .