Potential bioactive molecules from natural products to combat against coronavirus

Abstract

Covid-19 is terribly spreading around the globes and there is no stoppage. It is causing mass destruction in mankind allowing them to lock inside home to contain the disease. At present, there are no remedial medicines, drugs, or vaccines available in the market. Researchers are trying their best level to produce drugs to fight againts the disease. Various efforts are being considered by using different directions of scientific knowledge and technologies on treating the disease. The existing antiviral drugs such as lopinavir/ritonavir, pitavastatin, nelfinavir, perampanel, and praziquantel are being administered as remedies of covid-19 patients. Unfortunately, none of these drugs works absolutely against the current pandemic. Therefore, bioactive molecules from plants, animals, and microorganisms could be a better option to treat against the covid-19 and its family. Plants can treat many diseases due to the presence of bioactive molecules and their antiviral properties. Presence of secondary metabolites such as flavonoids, alkaloids, terpenoids, polyphenols, curcumin, kaempferol, catechin, naringenin, quercetin, apigenin-7-glucoside, luteolin-7-glucoside, demethoxycurcumin, oleuropein, and epigallocatechin can fight against the coronavirus including covid-19. The listed plants such as litchi seeds, Houttuynia cordata, Chinese Rhubarb extracts, beta-sistosterol from Isatis indigotica root extract have capacity to obstruct the enzymatic activity of SARS. In this article, we have highlighted the bioactive molecules from different plants, animals, and microorganism and their potential activity against the coronavirus. It is a need of the hour to come together to explore more on such bioactive compounds of plants, animals and other microorganism to fight against the covid-19.