Synthesis of novel homo-N-nucleoside analogs composed of a homo-1,4-dioxane sugar analog and substituted 1,3,5-triazine base equivalents

Abstract

Enantioselective syntheses from dimethyl tartrate of 1,3,5-triazine homo-Nnucleoside analogs, containing a 1,4-dioxane moiety replacing the sugar unit in natural nucleosides, were accomplished. The triazine heterocycle in the nucleoside analogs was further substituted with combinations of NH2, OH and Cl in the 2,4-triazine positions. © 2008 by the authors; licensee Molecular Diversity Preservation International.