A preliminary study of THC-LSD interactions on rabbit EEG and behavior

Abstract

Quantified cortical and hippocampal electroencephalograms (EEG) and corresponding behaviors were recorded from rabbits who were given either acute or subacute (12-day) delta-9- tetrahydrocannabinol (THC;.5 mg/kg, iv) followed by acute lysergic acid diethylamide (LSD; 50 μg/kg, iv). The results indicated that acute THC does not block the stimulant effects of LSD (increases in standing and activity). However, subacute THC produced tolerance to the depressant cortical EEG (increase in delta) and behavioral (sprawling) activity of the cannabinoid and blocked some excitatory effects of LSD. © 1981, Psychonomic Society, Inc.. All rights reserved.