Coagulopathy and functional hyposplenism during an episode of thrombotic thrombocytopenic purpura in a HgbS/ β + ‐thalassemia patient

Abstract

We report a case of TTP in a sickle cell/ β +‐thalassemia heterozygote with nonspecific complaints and a evidence of hemolysis, initially attributed to sickle crisis. Included in this case is a discussion of the development of functional hyposplenism, a rarely reported complication, limitation of ADAMTS ‐13 in diagnosis, and the use of platelet transfusion.