Thio-Schiff bases derived from 2,2’-disulfanedianiline via nanocerium oxide: antimicrobial effect and antiproliferative effects in melanoma cells

Abstract

In this study, the synthesis of dimeric disulfide-Schiff bases was carried out using two methods. The structures of the obtained Schiff bases were elucidated by various spectroscopic methods as well as elemental analysis. The Schiff base derivative compounds (3a-6) were screened for in vitro antibacterial activity against multidrug-resistant microorganisms using microdilution method. All the tested compounds showed varying inhibition zones against the pathogens. According to MIC results, the compound 2 was shown strong inhibitory activity against all the tested microorganisms compared to antibiotics. In addition, all the tested compounds showed different antiproliferative effects on the melanoma cell line (B16F10). Our synthesized dimeric disulfide-Schiff bases have shown significant various effects.