IGFBP-2 (1) has been described as a brain tumor oncogene (2) and is widely expressed in cancers from different origins (3-8). IGFBP-2 alone cannot cause malignant transformation, yet progression of brain tumors to higher grade (9) and also has been provided as a protective element in earlier stages of multistage colon carcinogenesis (10). Therefore, it is crucial to understand the factors that determine expression patterns of IGFBP-2 under normal and malignant conditions. The present review provides a comprehensive update of known factors that have an impact on expression of IGFBP-2. © 2014 Hoeflich, Wirthgen, David, Classen, Spitschak and Brenmoehl.
CITATION STYLE
Hoeflich, A., Wirthgen, E., David, R., Classen, C. F., Spitschak, M., & Brenmoehl, J. (2014). Control of IGFBP-2 expression by steroids and peptide hormones in vertebrates. Frontiers in Endocrinology. Frontiers Research Foundation. https://doi.org/10.3389/fendo.2014.00043
Mendeley helps you to discover research relevant for your work.