The 28-Day Mortality Outcome of the Complete Hour-1 Sepsis Bundle in the Emergency Department

Abstract

Introduction:The Surviving Sepsis Campaign published the Hour-1 Sepsis Bundle in 2018. The first-hour management of patients with sepsis in the emergency department (ED) is important, as suggested in the Hour-1 Sepsis Bundle. The objectives of the present study were to evaluate 28-day mortality and delayed septic shock with use of a complete and incomplete Hour-1 Sepsis Bundle in the ED.Methods:This prospective cohort study included adult patients with sepsis from March to July 2019. We followed the sepsis protocol used in the ED of a tertiary care hospital.Results:We enrolled 593 patients, with 55.9% in the complete Hour-1 Sepsis Bundle group. The 28-day mortality was 3.9% overall and no significant difference between the complete and incomplete Hour-1 Sepsis Bundle groups (3.6% vs. 4.2%, P=0.707). Complete Hour-1 Sepsis Bundle treatment was not associated with 28-day mortality (adjusted OR=2.04, 95% confidence interval [CI]=0.72-5.74, P=0.176) or delayed septic shock (adjusted OR=0.74, 95% CI=0.30-1.78, P=0.499). Completion of each bundle did not affect outcomes of 28-day mortality and delayed septic shock.Conclusions:The complete Hour-1 Sepsis Bundle treatment in the ED was not significantly associated with 28-day mortality and delayed septic shock.