Neutrophilic Dermatoses Revisited

Abstract

The neutrophilic dermatoses (ND) comprise a group of heterogeneous disorders characterised by inflammatory skin lesions that histologically show an intense inflammatory infiltrate composed primarily by neutrophils, with no evidence of infection. Although there are distinct clinical differences in the classical lesions of these disorders, many patients have overlapping features. In this mini-review we describe the clinical aspects of the main NDs, including: Sweet’s syndrome, neutrophilic dermatosis of the dorsal hands, pyoderma gangrenosum, erythema elevatum diutinum, subcorneal pustular dermatosis, neutrophilic eccrine hidradenitis, rheumatoid neutrophilic dermatitis, neutrophilic panniculitis, and aseptic abscesses, their association with underlying diseases, differential diagnosis, treatment options, and prognosis.