Mitochondrial energy metabolism and redox state in dyslipidemias

Abstract

Changes in mitochondrial function are intimately associated with metabolic diseases. Here, we review recent evidence relating alterations in mitochondrial energy metabolism, ion transport and redox state in hypercholesterolemia and hypertriglyceridemia. We focus mainly on changes in mitochondrial respiration, K+ and Ca2+ transport, reactive oxygen species generation and susceptibility to mitochondrial permeability transition. © 2007 IUBMB.