Simple bedside score to optimize the time and the decision to initiate appropriate therapy for carbapenem-resistant Enterobacteriaceae

Abstract

Background: Epidemiological characteristics of patients with bloodstream infections (BSI) due to extended-spectrum ß-lactamase producing (ESBL) and carbapenem-resistant (CRE) strains are often similar. Mortality rates for CREBSI are 70 %, and mean time to initiation of appropriate therapy is ~5 days. A bedside score was developed to differentiate CRE-BSIs from ESBL-BSIs, in order to help decrease the time to initiation of appropriate therapy for CRE and mortality rates.Findings: Score was developed based of data (2007-2010) abstracted from charts of adult patients from Assaf Harofeh Medical Center (AHMC, Zeriffin, Israel), and validated on a cohort of patients from Detroit Medical Center(DMC, MI, USA). A multivariate model for presence of CRE was generated. A clinical prediction score and ROC curve was derived. 451 patients with ESBL BSIs (285 from AHMC and 166 from DMC) and 74 patients with CREBSIs (58 from AHMC and 16 from DMC) were included. The prediction score included chemotherapy in the past3 months (19 points), presence of foreign invasive devices (10 points), no peripheral vascular disease (10 points),reduced consciousness or cognition at time of acute illness (9 points), time in hospital prior to BSI = 3 days(7 points), and age younger than 65 years (6 points). A score of =32 to define "high CRE risk" had sensitivity of 59 %, specificity of 76 %, PPV of 34 % and NPV of 90 %.Conclusions: The score's 90 % NPV implies it could reduce un-necessary (and toxic) empiric use of anti-CRE therapeutics, but this should be studied prospectively and on broader populations in order to test its potential role in reducing mortality.