“Organs on a Chip”: Revolutionization in personalized treatment

Abstract

“Organs-on-a-chip” (OOAC), involves microfluidics based biomaterial sciences, bio-engineering and cell biology majorly cell isolation and cell culturing aspects. This technology claims to develop 3-dimensional tissues structurally and physiologically in simulation to in vivo providing relevant results in terms of physiological and genetic aspects with virtue of its origin from human systems. In recent times, experts from diversified disciplines have developed and established many OOAC systems with an assertion of being perfect for drug research replacing convectional cell cultures and animal testing due to the technical limitations in the applicability  of the same in vivo for systemic complexities and genetic variances. “Organs-on-a-chip” has attracted substantial interest for its wide range of applications in fields of drug research, regenerative medicine and personalized medicine. Successful development and establishments of different OOACs will contribute towards newer avenues in the path of precised personalized medicine.  Keywords: Organs on a chip, personalized medicine, OOAC, 3D cell culture