Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization

Abstract

A mild and practical synthesis of spirooxindole [1,3]oxazino derivatives from N-substituted isatins and 1,3-dicarbonyl compounds with pyridine derivatives is reported. The reactions provided good to excellent yields. Further exploration of the molecular diversity of these compounds is demonstrated through Diels - Alder reactions. © 2012 Dai et al.