Pan-genus analysis and typing of antimicrobial resistance plasmids in Acinetobacter

Abstract

Plasmids play a central role in horizontal gene transfer and bacterial adaptation, especially in the context of antimicrobial resistance (AMR) among opportunistic pathogens. Some members of the genus Acinet obacter are known for their role in hospital-acquired infections, harboring plasmids that facilitate rapid adaptation to selective pressures. However, the extent of plasmid diversity and evolutionary dynamics within Acinet obacter has not been fully elucidated. In this study, we analysed 1,848 complete and non-redundant Acinet obacter plasmid sequences, identifying 120 novel Replicase (Rep) protein types and providing a signi