An integrated technology for quantitative wide mutational scanning of human antibody Fab libraries

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Abstract

Limited experimental platforms exist for assessing quantitative sequence-function relationships for multiple antibodies. Here, authors develop a deep-sequencing based technology called MAGMA-seq, that determines the quantitative properties of antibody libraries.

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Petersen, B. M., Kirby, M. B., Chrispens, K. M., Irvin, O. M., Strawn, I. K., Haas, C. M., … Whitehead, T. A. (2024). An integrated technology for quantitative wide mutational scanning of human antibody Fab libraries. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-48072-z

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