The in vivo and in vitro mechanistic anti-inflammatory actions of cucurbitacin E (CE) (Citrullus lanatus var. citroides) were examined. The results showed that LPS/INF-γ increased NO production in RAW264.7 macrophages, whereas L-NAME and CE curtailed it. CE did not reveal any cytotoxicity on RAW264.7 and WRL-68 cells. CE inhibited both COX enzymes with more selectivity toward COX-2. Intraperitoneal injection of CE significantly suppressed carrageenan-induced rat's paw edema. ORAC and FRAP assays showed that CE is not a potent ROS scavenger. It could be concluded that CE is potentially useful in treating inflammation through the inhibition of COX and RNS but not ROS. © 2011 Elsevier B.V. All rights reserved.
CITATION STYLE
Abdelwahab, S. I., Hassan, L. E. A., Sirat, H. M., Yagi, S. M. A., Koko, W. S., Mohan, S., … Hadi, A. H. A. (2011). Anti-inflammatory activities of cucurbitacin e isolated from Citrullus lanatus var. citroides: Role of reactive nitrogen species and cyclooxygenase enzyme inhibition. Fitoterapia, 82(8), 1190–1197. https://doi.org/10.1016/j.fitote.2011.08.002
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